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Vascular and circulatory diseases of the retina associated with spent Covid-19- clinical cases 

Volume 10, Issue 1

Case Report / Published: July 2022


Т. Kirova, A. Kalaydzhiev, L. Voynov

Clinic of Ophthalmology, Department of Ophthalmology, Otorhinolaryngology and Oral Surgery, Military Medical Academy, Sofia, Bulgaria


Coronavirus disease 2019 has affected more than 130 million people since the outbreak. During the pandemic, the severe acute respiratory syndrome virus (SARS-CoV-2) was found to cause endothelial dysfunction of small blood vessels and can lead to late ocular complications such as acute occlusion of the central retinal artery and its branches, occlusion of the venous vessels of the retina, central serous retinopathy, papillophlebitis, anterior ischemic opticopathy, uveitis and neuroretinitis.

The aim of the present study was to raise awareness of the risk of developing acute retinal vascular disease associated with COVID-19. 



  1. Wong NA, Saier MH Jr. The SARS-Coronavirus Infection Cycle: A Survey of Viral Membrane Pro- teins, Their Functional Interactions and Patho- genesis. Int J Mol Sci. 2021; 22(3):1308. Published 2021 Jan 28. doi:10.3390/ijms22031308 
  2. Hooper LC, Chin MS, Detrick B, Hooks JJ. Retinal degeneration in experimental coronavirus reti- nopathy (ECOR) is associated with increased TNF- alpha, soluble TNFR2 and altered TNF-alpha signaling. J Neuroimmunol. 2005; 166(1-2):65-74. doi:10.1016/j.jneuroim. 2005.05.018 
  3. ZhouY, DuanC, ZengY, et al. Ocular findings and proportion with conjunctival SARS-COV-2 in COVID-19 patients. Ophthalmology. 2020. doi:10.1016/j.ophtha.2020.04.028. 
  4. Lecler A, Cotton F, Lersy F, et al. SFNR’s COVID Study Group. Ocular MRI Findings in Patients with Severe COVID-19: A Retrospective Multicenter Observational Study [published online ahead of print, 2021 Feb 16]. Radiology. 2021; 204394. doi:10.1148/radiol.2021204394 
  5. Sim R, Cheung G, Ting D, et al. Retinal microvas- cular signs in COVID-19 [published online ahead of print, 2021 Mar 19]. Br J Ophthalmol. 2021; bjophthalmol-2020-318236. doi:10.1136/bjoph- thalmol-2020-318236 
  6. Gupta A, Dixit B, Stamoulas K, Akshikar R. Atypical bilateral acute retinal necrosis in a coronavirus dis- ease 2019 positive immunosuppressed patient. Eur J Ophthalmol. 2020 Nov 22:1120672120974941. doi: 10.1177/1120672120974941 
  7. Tisdale AK, Chwalisz BK. Neuro-ophthalmic mani- festations of coronavirus disease 19. Curr Opin Ophthalmol. 2020 Nov; 31(6):489-494. doi: 10.1097/ICU.0000000000000707 
  8. ОЧНИ ПРОЯВИ ПРИ COVID-19 – КЛИНИЧНИ СЛУЧАИ И ПРЕГЛЕД НА ЛИТЕРАТУРАТА А. Оскар1, Я. Здравков1, Р. Христова1, Г. Марков1, А. Георгиева2, Л. Шахинян2, К. Телбизова2, М. Методиева2, Г. Цветкова1, И. Петкова, БЪЛГАРСКИ ОФТАЛМОЛОГИЧЕН ПРЕГЛЕД, 2021, 65, бр. 2 
  9. Klok FA, Kruip MJHA, van der Meer NJM, et al. In- cidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020 Jul; 191:145-147. 
  10. Yang L, Liu S, Liu J, et al. COVID-19: immunopatho- genesis and Immunotherapeutics. Signal Trans- duct Target Ther. 2020; 5(1):128. doi:10.1038/ s41392-020-00243-2 
  11. Casagrande M, Fitzek A, Püschel K, et al. Detection of SARS-CoV-2 in human retinal biopsies of deceased COVID-19 patients. Ocul Immunol Inflamm 2020; 28: 721–725
  12. Marinho PM, Marcos AAA, Romano AC, et al. Retinal findings in patients with COVID-19. Lancet 2020; 395: 1610.
  13. Riotto, E.; Mégevand, V.; Mégevand, A.; Marti, C.; Pugin, J.; Stangos,   A.N.; Marconi Archinto, L.; Sunaric Mégevand, G. Retinal Manifestations in Patients with COVID-19: A Prospective Cohort Study. J. Clin. Med. 2022, 11, 1828. jcm11071828
Click to review Volume 10, Issue 1


COVID-19, endothelial dysfunction, vascular diseases,thrombosis

How to cite this article:

Kirova T, Kalaydzhiev A, Voynov L.Vascular and circulatory diseases of the retina associated with spent Covid-19- clinical cases. Journal of Endourology and Minimally Invasive Surgery (Bulgaria), 2022; 10(1):56-60

Corresponding author:

Dr. Tanislava Kirova

Clinic of Ophtalmology

Military Medical Academy of Sofia

Address: 3, Sv. Georgi Sofiyski blvd, 1606, Sofia

E-mail: tanislava.kirova @