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Role of nuclear medicine SPECT-CT methods in the diagnosis of Urinary Tract Urothelial Cell Cancer

By Boris

Volume 9, Issue 1

Original Article / Published: November 2021

DOI: https://www.doi.org/10.57045/jemis/911121.pp5-16

S. Sergieva1, A. Fakirova2, B. Ilcheva2, M. Dimcheva3, R. Mangaldgiev4, O. Gatsev5, K. Petkova5, I.Saltirov5

  1. Department of Nuclear Medicine, Sofia Cancer Center, Sofia
  2. Department of General and Clinical Pathology, Military Medical Academy, Sofia
  3. Department of Nuclear Medicine, Sofia Cancer Center, Sofia
  4. Department of Medical Oncology, Sofia Cancer Center, Sofia
  5. Department of Urology and Nephrology, Military Medical Academy, Sofia, Bulgaria

Abstract

Nuclear medicine methods, with subsequent hybrid SPECT-CT images, are highly sensitive and specific visual methods that establish the functional status of the target organs, diagnose and stage pathological secondary lesions with increased mineral activity in bone and joint structures and determine the exact localization, anatomical structure and the corresponding morphological characteristics of the tumors localized in the lower and upper urinary tract. Urothelial carcinomas develop in the process of malignant transformation of cells of the transitional epithelium. Depending on their location, urothelial tumors are divided into those that develop in the lower urinary tract (bladder, urethra) and in the upper urinary tract (ureters and collecting system of both kidneys). Whole-body bone scintigraphy and dynamic nephroscintigraphy with subsequent targeted SPECT-CT studies are of great clinical importance in patients with these oncological localizations for the accurate diagnosis and staging of bone secondary lesions, for visualization of obstructive hydronephrosis and relative renal function, especially in high-risk patients.

 

References

  1. A. Horwich , M. Babjuk, J. Bellmunt, H. M. Bruins, T. M. De Reijke, M. De Santis et al. EAU–ESMO consensus statements on the management of advanced and variant bladder cancer—an international collaborativ Annals of Oncology30: 1697–1727, 2019.
  2. J.D.Brierley, M.K.Gospodariwicz, K.Wittekind. TNM Classification of Malignant Tumors, UICC 8th Edition. New York: Wiley, 2017.
  3. Ro JY, Staerkel GA, Ayala AG. Cytologic and histologic features of superficial bladder cancer. Urol Clin North Am. 1992;19:435–453.
  4. Holmang S, Hedelin H, Anderstrom C, Johansson SL. The relationship among multiple recurrences, progression and prognosis of patients with stages Ta and T1 transitional cell cancer of the bladder followed for at least 20 years. J Urol. 1995;153:1823–1826. discussion 1826-1827.
  5. Steven K, Poulsen AL. Radical cystectomy and extended pelvic lymphadenectomy: survival of patients with lymph node metastasis above the bifurcation of the common iliac vessels treated with surgery only. J Urol. 2007;178:1218–1223. discussion 1223-1224.
  6. Turner RM II, Yabes JG, Davies BJ, Heron DE, Jacobs BL. Variations in Preoperative Use of Bone Scan among Madicare Beneficiaries Undergoing Radical Cystectomy. 2017; 103:84-90.
  7. Fogelman I, Blake GM, Cook GJ. The isotope bone scan: we can do better. Eur J Nucl Med Mol Imaging 2013; 40: 1139 –1140.
  8. Sergieva S, Alexandrova E, Robev B, Mihaylova I, Dimcheva M. Bone SPECT-CT in diagnosis and staging of osseous metastases. PJNM 2015;5:1-
  9. Sergieva S., I.Mihailova, E. Alexandrova et al. SPECT/CT in radiotherapy planning. Curr.Radiopharm. 2015;8:9-18.
  10. S. Sergieva, B. Robev, M.Dimcheva. Whole body bone scan followed by SPECT-CT in diagnosis, staging and follow-up of tumor-induced bone disease in patients with urogenital neoplasms. 3rd Meeting of ESUI, 13-16 Nov 2014 Lisbon, Portugal. Eur J Urology, Suppl. 2014;13(5):pp177-178, EP 171.
  11. Taher AN, Kotb MH. Bone metastases in mucle-invasive bladder cancer. J Egypt Natl Canc Inst. 2006; 18(3): 203-208.
  12. Siegel, R.L., et al. Cancer statistics, 2017. CA Cancer J Clin, 2017. 66: 7.
  13. Krambeck AE, Thompson RH, Lohse CM, et al. Imperative indications for conservative management of upper tract transitional cell carcinoma. J Urol. 2007;178:792–7. [PubMed] [Google Scholar]
  14. Margulis, V., et al. Outcomes of radical nephroureterectomy: a series from the Upper Tract Urothelial Carcinoma Collaboration. Cancer, 2009. 115: 1224.
  15. Soria, F., et al. Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC). World J Urol, 2017. 35: 379.
  16. Seisen, T., et al. A Systematic Review and Meta-analysis of Clinicopathologic Factors Linked to Intravesical Recurrence After Radical Nephroureterectomy to Treat Upper Tract Urothelial Carcinoma. Eur Urol, 2015. 67: 1122.
  17. Cutress, M.L., et al. Long-term endoscopic management of upper tract urothelial carcinoma: 20-year single-centre experience. BJU Int, 2012. 110: 1608.
  18. И. Салтиров, Ц. Петков, Г. Георгиев, К. Петкова, Ендоскопска уретеректомия при нефроуретеректомия за преходноклетъчен карцином на горния уринарен тракт. J Clin Med. 2010; 3(1):24-30
  19. П. Петров, С. Христофоров ,О. Гъцев, К. Петкова, Д. Петрова, И. Салтиров, Ендоурологично лечение на преходноклетъчни тумори на горен уринарен тракт, Ендоурология и минимално инвазивна хирургия. 2019;7(1):30-35
  20. Roupret M, Zigeuner R, Palou J, et al. European guidelines for the diagnosis and management of upper urinary tract urothelial cell carcinomas: 2011 update. Eur Urol. 2011;59:584–594. doi: 10.1016/j.eururo.2010.12.042. [PubMed] [CrossRef]
  21. Pablo Garrido Abad, Almudena Coloma del Peso, and Manuel Fernández Arjona Holmium:YAG laser ablation of upper urinary tract transitional cell carcinoma with new Olympus digital flexible ureteroscope Urol Ann. 2013 Jul-Sep; 5(3): 212–214. doi: 10.4103/0974-7796.115748
  22. Roupret M., Babjuk M., Burger M, Comperat E, Cowan NC, Gontero P. et al. EAU Guidelines on Upper Urinary Tract Urothelial Carcinoma 2018. Archem, The Netherlands.
  23. Amirian MJ, Radadia K, Narins H, et al. The significance of functional renal obstruction in predicting pathologic stage of upper tract urothelial carcinoma. J Endourol. 2014;28(11):1379-1383.
  24. Fried J.G., Morgan M.A. Renal Imaging: Core Curriculum 2019. Am J Kidney Dis. 2019; 73(4): 552-565.
  25. Park, J., Bae, S., Seo, S. et al. Measurement of Glomerular Filtration Rate using Quantitative SPECT/CT and Deep-learning-based Kidney Segmentation. Sci Rep. 2019; 9: 4223.
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Keywords:

urothelial carcinomas, SPECT-CT, dynamic nephroscintigraphy, bone scintigraphy

How to cite this article:

S.Sergieva, A. Fakirova, B. Ilcheva, M. Dimcheva, R.Mangaldgiev, O. Gatsev, K. Petkova, I. Saltirov. Role of nuclear medicine SPECT-CT methods in the diagnosis of urinary Tract Urothelial Cell Cancer. Journal of endourology and Minimally Invasive Surgery (Bulgaria)2021; 9 (1): 5-16

Corresponding author:

Prof. Sonya Sergieva MD, Phd;

Head, Department of Nuclear Medicine, Sofia Cancer Center

Blvd. “Andrey Saharov”22, Sofia – 1784, Bulgariae

E-mail: sergieva.sonya@yahoo.com