Volume 12, Issue 1
Original Article / Published: December 2024
DOI:
Albena Fakirova
Clinic of Pathology, Military Medical Academy, Sofia
Abstract
Nowadays, numerous reoccurring epidemiologic, histopathologic and molecular-genetic evidence of the connection between chronic inflammation and socially significant prostate diseases can be traced, such as benign prostate hyperplasia, prostate cancer and prostatitis. At the same time, however, for many years the intermediate link between the initial process (chronic inflammation) and the end stage (prostate cancer) of the morphogenesis of the process was not clearly defined. Nevertheless, owing to the extensive and comprehensive research that has been conducted in the last 25 years, this gap has now been narrowed, and new histological entities have appeared, namely inflammatory proliferative atrophy and postatrophic hyperplasia (PAH). The plethora of terminology, associated with PAH, includes secondary hyperplasia, hyperplastic atrophy, lobular hyperplasia, small acinar proliferation and atrophy, associated with hyperplasia.
The purpose of this article is to provide an overview of the current morphological and immunohistochemical characteristics of PAH, drawing from the existing literature on this topic. A summary of suggestions for further research in the future is also included.
References
1. Amin MB, Tamboli P, Varma M, Srigley JR. Postatrophic morphology in needle biopsy specimens. Am J Surg Pathol. 1999;23:925-931.
2. Moore R A. The evolution and involution of the prostate gland. Am J Pathol. 1936;12:599-624.
3. Totten RS. Some experiences with latent carcinoma of the prostate. Bull N Y Acad Med. 1953;29:579-582.
4. Franks LM. Atrophy and hyperplasia in the prostate proper. J Pathol Bacteriol. 1954;68:617-21.
5. Liavåg I. Atrophy and regeneration in the pathogenesis of prostate carcinoma. Acta Pathol Microbiol Scand. 1968;73:338.
6. Billis A. Prostatic atrophy: an autopsy study of a histologic
mimic of adenocarcinoma. Mod Pathol. 1998;11:47-54.
7. Ruska KM, Sauvageot J, Epstein JI. Histology and cellular kinetics of prostatic atrophy. Am J Surg Pathol.1998;1073-78. De Marzo AM, Marchi VL, Epstein JI, Nelson WG. Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis. Am J Pathol.1999;155:1985-1992.
9. Караиванов М. Препъникамъчета в диагнозата на простатният карцином. VI Национален конгрес по патология. Стара Загора. 24-26 септември 1998
10. Anton RC, Kattan MW, Chakraborty S, Wheeler TM. Postatrophic hyperplasia of the prostate: lack of association with prostate cancer. Am J Surg Pathol. 1999;23:932-6. doi: 10.1097/00000478-199908000-00011. PMID: 10435563.
11. Shah R, Mucci NR, Amin A, Macoska JA, Rubin MA. Postatrophic hyperplasia of the prostate gland: neoplastic precursor or innocent bystander? Am J Pathol. 2001 May;158(5):1767-73.
12. Srigley JR. Benign mimickers of prostatic adenocarcinoma.Mod Pathol. 2004;17: 328-348.
13. McNeal JE. Regional morphology and pathology of the prostate. Am J Clin Pathol. 1968;43:347-357.
14. Атанасов Т, Валерианова З, Вуков М, Грозева Т, Йорданова М, Кунева Т, Петкова Й, Узунова Л. Таблици, фигури иприложения, 2015. Валерианова З, Атанасов Т, Вуков М. ,,Заболяемост от рак в България, 2014 и 2015’’.
Български национален раков регистър. София, България: Издателство ,,Парадигма‘‘, 2017, Publisher ,,Paradigma’’ 2017, ISSN:1314-7315, 2017; Том XXV:147стр.
15. Bostwick DG, Hull D, Ma J, Hossain D. Nonneoplastic diseases of the prostate. In:Bostwick DG, Cheng L, eds. Urologic Surgical Pathology. 3th ed. Philadelphia, PA, USA: Elsevier Saunders; 2014:352-407.
16. Wernert N, Seitz G, Achtstätter T. Immunohistochemical investigation of different cytokeratins and vimentin in the prostate from the fetal period up to adulthood and in prostate carcinoma. Pathol Res Pract 1987;182:617-626.
17. Humphrey PA. Nonneoplastic diseases of the prostate and seminal vesicles. In: Amin MB, Eble JN, eds. Urological Pathology. Philadelphia, PA, USA: Lippincott Williams & Wilkins Kluwer; 2014:491-522.
18. Egevad L, Delahunt B, Furusato B, Tsuzuki T, Yaxley J, Samaratunga H. Benign mimics of prostate cancer. Pathology. 2021;53:26-35.
19. Караиванов М, Иванова В. Хистологична диференциална диагноза на простатния карцином. Българска медицина. 2003;9(5):11-1513.
Keywords:
prostate, post-atrophic hyperplasia, chronic inflammation, adenocarcinoma
How to cite this article:
A. Fakirova Postatrophic hyperplasia of the prostate: Current literature review and research perspectives; Journal of Endourology and Minimally Invasive Surgery, 2024; 11(1): 5-11
Corresponding author:
Albena Docheva Fakirova
Military Medical Academy, Sofia, Clinic of Pathology, 3 “Georgi Sofiiski,
e-mail: afakirova@gmail.com