Volume 13, Supplement 1
Original Article / Published: April 2025
DOI: https://www.doi.org/10.57045/jemis/1310425.pp22-23
D.Petrova , K. Petkova O. Gatsev, K. Hristov, V. Todorova,I. Saltirov
Department of Urology and Nephrology, Military Medical Academy, Sofia, Bulgaria
Abstract
Introduction & Objectives: Nephrolithiasis-associated renal damage is an important potential contributor to the risk of CKD and has been investigated by numerous studies. Metabolic disorders such as hypercalciuria, hyperoxaluria and hypocitraturia are commonly diagnosed in calcium oxalate stone formers. The objective of this study is to compare the presence of metabolic disorders in calcium oxalate stone formers with CKD and normal renal function.
Materials and methods: A prospective study on 111 patients with calcium oxalate urolithiasis was performed between January 2022 and July 2024. All patients underwent serum creatinine testing and eGFR calculation and metabolic evaluation with 24h-urine collection one month after endourological treatment or spontaneous stone elimination. The rate of hypercalciuria, hyperoxaluria and hypocitraturia in relation to CKD was analyzed. We define CKD as either kidney damage or a decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73 m2.
Results: CKD was found in 20 (18%) of all patients, 11(9.9%) male and 9(8.1%) female. The incidence of CKD is high in patients with more than one recurrence- 12.6% vs 5.4%( first recurrence); 8(40%) of patients with a family history of stone disease have CKD. The most common comorbidity in patients with CKD is hypertension-10(50%). CKD was found in 0.9% of patients with hyperuricosuria, 9.9% of hypocitraturia, 9% of hyperoxaluria-high and moderate and 7.2% of hypercalciuria.
Conclusions: The results of our study suggest that calcium oxalate urolithiasis is associated with a higher risk of CKD. The number of stone episodes is associated with a decrease in kidney function. Metabolic disorders such as hypercalciuria, hyperoxaluria and hypocitraturia are commonly found in calcium oxalate stone formers with CKD. Identification of risk factors for stone recurrence and intervention with appropriate treatment may prevent or reduce recurrence rates and the risk of ESRD.
References
Keywords:
Chronic kidney disease, Urolithiasis, Hypercalciuria, Hyperoxaluria, Hypocitraturia
How to cite this article:
D.Petrova , K. Petkova O. Gatsev, K. Hristov, V. Todorova,I. Saltirov. CKD in patients with calcium oxalate urolithiasis Journal of Endourology and Minimally Invasive Surgery (Bulgaria), 2025; 13(1): 22-23
Corresponding author:
Assoc. Prof. Daniela Petrova
Clinic of Nephrology Department of Urology and Nephrology Military Medical Academy
Address: Sofia 1606, 3, Georgi Sofiyski Blvd.
Email: dan_pertova@abv.bg