{"id":1964,"date":"2025-09-17T20:50:03","date_gmt":"2025-09-17T17:50:03","guid":{"rendered":"https:\/\/jemis.org\/?page_id=1964"},"modified":"2026-01-26T11:22:18","modified_gmt":"2026-01-26T09:22:18","slug":"laboratory-evaluation-of-primaryhyperparathyroidism-in-patientswith-urolithiasis","status":"publish","type":"page","link":"https:\/\/jemis.org\/bg\/laboratory-evaluation-of-primaryhyperparathyroidism-in-patientswith-urolithiasis\/","title":{"rendered":"\u041a\u043b\u0438\u043d\u0438\u0447\u043d\u043e-\u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u0430 \u043e\u0446\u0435\u043d\u043a\u0430 \u043d\u0430 \u043f\u044a\u0440\u0432\u0438\u0447\u0435\u043d \u0445\u0438\u043f\u0435\u0440\u043f\u0430\u0440\u0430\u0442\u0438\u0440\u0435\u043e\u0438\u0434\u0438\u0437\u044a\u043c \u043f\u0440\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0438 \u0441\n\u0443\u0440\u043e\u043b\u0438\u0442\u0438\u0430\u0437\u0430"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p class=\"wp-block-paragraph\"><em><strong>Volume 13,<\/strong><\/em> <strong>Issue 1<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Original Article \/ Published: September 2025<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">DOI: <a href=\"https:\/\/www.doi.org\/10.57045\/jemis\/1310925.pp52-53\">https:\/\/www.doi.org\/10.57045\/jemis\/1310925.pp52-53<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">M. Nistorova\u00b9,\u00b3, V. Racheva\u00b9,\u00b3, A. Ruseva\u00b2,\u00b3, V. Dunev\u00b9,\u00b3, Zh. Atanasov\u00b9,\u00b3<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00b9 University Hospital \u201cSt. Marina\u201d , Pleven,\u00b2 University Hospital \u201cDr. Georgi Stranski\u201d, Pleven, \u00b3 Medical University, Pleven<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Background:<\/strong> Primary hyperparathyroidism (PHPT) is a common cause of hypercalcemia and a significant etiological factor in urolithiasis. Timely identification of biochemical abnormalities is crucial for diagnosis and management.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Objective:<\/strong> To assess the diagnostic value of serum calcium, phosphorus, parathyroid hormone (PTH), and vitamin D in detecting PHPT in patients with urolithiasis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Methods:<\/strong> The study included 210 patients with ultrasonographically confirmed urolithiasis. Serum calcium, phosphorus, PTH, and Vit. D levels were measured. Statistical analysis was performed using SPSS and Excel.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Results:<\/strong> Mean values were as follows: PTH \u2013 35.7 \u00b1 26.3 pg\/mL; calcium \u2013 2.42 \u00b1 0.20 mmol\/L; phosphorus \u2013 1.25 \u00b1 0.25 mmol\/L; vitamin D \u2013 21.2 ng\/mL. Vitamin D deficiency (&lt;20 ng\/mL) was observed in 50% of patients. A biochemical profile suggestive of normocalcemic PHPT was present in 10%. A weak but statistically significant correlation was found between serum calcium and PTH (r = 0.25; p = 0.00028).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Conclusion:<\/strong> A significant proportion of patients with urolithiasis have laboratory findings indicative of PHPT, including the normocalcemic form. Routine measurement of calcium and PTH is recommended, especially in recurrent stone formers.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>References<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">1.Marcocci C, Cetani F. Primary hyperparathyroidism. Lancet Diabetes Endocrinol. 2021;9(2):109\u2013118.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2. Silverberg SJ, Bilezikian JP. Non-classical target organs in primary hyperparathyroidism. J Clin Endocrinol Metab. 2020;105(12):dgaa551.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">3. Bilezikian JP, et al. Guidelines for the management of asymptomatic primary hyperparathyroidism. J Clin Endocrinol Metab. 2014;99(10):3561\u20133569.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">4. Walker MD, Silverberg SJ. Primary hyperparathyroidism. NatRev Endocrinol. 2018;14(2):115\u2013125.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">5. Yeh MW, Ituarte PHG, et al. Incidence and prevalence of primary hyperparathyroidism in a racially diverse population. JClin Endocrinol Metab. 2013;98(3):1122\u20131129.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">6. Cipriani C, et al. Normocalcemic primary hyperparathyroidism. J Clin Densitom. 2017;20(4):402\u2013413.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">7. Ferraro PM, et al. The role of vitamin D in nephrolithiasis. J Endocrinol Invest. 2020;43(4):413\u2013419.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/jemis.org\/wp-content\/uploads\/2026\/01\/JEMIS_2025_13_1-6.pdf\" target=\"_blank\" rel=\" noreferrer noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"707\" height=\"872\" data-id=\"1921\" src=\"https:\/\/jemis.org\/wp-content\/uploads\/2026\/01\/Jemis_2025_September_13_1.png\" alt=\"\" class=\"wp-image-1921\" srcset=\"https:\/\/jemis.org\/wp-content\/uploads\/2026\/01\/Jemis_2025_September_13_1.png 707w, https:\/\/jemis.org\/wp-content\/uploads\/2026\/01\/Jemis_2025_September_13_1-243x300.png 243w, https:\/\/jemis.org\/wp-content\/uploads\/2026\/01\/Jemis_2025_September_13_1-10x12.png 10w\" sizes=\"auto, (max-width: 707px) 100vw, 707px\" \/><\/a><figcaption class=\"wp-element-caption\">Volume 11, Issue 1<\/figcaption><\/figure>\n<\/figure>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button has-custom-width wp-block-button__width-100 is-style-fill\"><a class=\"wp-block-button__link has-light-gray-color has-text-color wp-element-button\" href=\"https:\/\/jemis.org\/wp-content\/uploads\/2026\/01\/JEMIS_2025_13_1-6.pdf\" style=\"border-radius:8px\">Article [pdf]<\/a><\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Keywords<\/strong>: <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">primary hyperparathyroidism, urolithiasis, parathyroid hormone,<br>vitamin D, calcium<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>How to cite this article<\/strong>:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">M. Nistorova, V. Racheva, A. Ruseva, V. Dunev, Zh. Atanasov. Laboratory Evaluation of Primary Hyperparathyroidism in Patients with urolithiasis . Journal of Endourology and Minimally Invasive Surgery (Bulgaria), 2025; 13(1): 52-53<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Corresponding author<\/strong>:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. L. El-Tal<br>Clinic of Hepatobiliary, Pancreatic and General Surgery<br>Acibadem City Clinic Tokuda Hospital<br>51B Nikola Vaptsarov Blvd<br>e-mail: &nbsp;<a href=\"mailto:luben.eltal@gmail.com\">luben.eltal@gmail.com<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Volume 13, Issue 1 Original Article \/ Published: September 2025<span class=\"more-button\"><a href=\"https:\/\/jemis.org\/bg\/laboratory-evaluation-of-primaryhyperparathyroidism-in-patientswith-urolithiasis\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\">\u041a\u043b\u0438\u043d\u0438\u0447\u043d\u043e-\u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u0430 \u043e\u0446\u0435\u043d\u043a\u0430 \u043d\u0430 \u043f\u044a\u0440\u0432\u0438\u0447\u0435\u043d \u0445\u0438\u043f\u0435\u0440\u043f\u0430\u0440\u0430\u0442\u0438\u0440\u0435\u043e\u0438\u0434\u0438\u0437\u044a\u043c \u043f\u0440\u0438 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0438 \u0441\n\u0443\u0440\u043e\u043b\u0438\u0442\u0438\u0430\u0437\u0430<\/span><\/a><\/span><\/p>","protected":false},"author":7,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/full-width-page.php","meta":{"footnotes":""},"class_list":["post-1964","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/jemis.org\/bg\/wp-json\/wp\/v2\/pages\/1964","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jemis.org\/bg\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/jemis.org\/bg\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/jemis.org\/bg\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/jemis.org\/bg\/wp-json\/wp\/v2\/comments?post=1964"}],"version-history":[{"count":5,"href":"https:\/\/jemis.org\/bg\/wp-json\/wp\/v2\/pages\/1964\/revisions"}],"predecessor-version":[{"id":2033,"href":"https:\/\/jemis.org\/bg\/wp-json\/wp\/v2\/pages\/1964\/revisions\/2033"}],"wp:attachment":[{"href":"https:\/\/jemis.org\/bg\/wp-json\/wp\/v2\/media?parent=1964"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}